2023
Scientists from Elphogene and the Genomac Research Institute in collaboration with leading Czech oncology centers have published an article in the international scientific journal World Journal of Gastroenterology.
The article entitled "Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating DNA tumor" was published on December 28, 2019 and summarizes the results of ctDNA analysis in 47 patients with metastatic colorectal cancer. The main outcome of this article is that ctDNA detection in patients with metastatic colorectal cancer is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment.
Ref.: Buresova M, Benesova L, Minarik M, Ptackova R, Halkova T, Hosek P, Baxa J, Pesek M, Svaton M, Fiala O. Circulating Tumor DNA correlates with Lactate Dehydrogenase, CYFRA 21-1, and CRP levels in patients with advanced NSCLC. J Cancer. 2023 Jan 1;14(1):1-8. doi: 10.7150/jca.78574. PMID: 36605490; PMCID: PMC9809334.
2022
Scientists from Elphogene and the Genomac Research Institute in collaboration with leading Czech oncology centers have published an article in the international scientific journal World Journal of Gastroenterology.
The article entitled "Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating DNA tumor" was published on December 28, 2019 and summarizes the results of ctDNA analysis in 47 patients with metastatic colorectal cancer. The main outcome of this article is that ctDNA detection in patients with metastatic colorectal cancer is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment.
Ref.: Benesova L, Ptackova R, Halkova T, Semyakina A, Svaton M, Fiala O, Pesek M, Minarik M. Detection and Quantification of ctDNA for Longitudinal Monitoring of Treatment in Non-Small Cell Lung Cancer Patients Using a Universal Mutant Detection Assay by Denaturing Capillary Electrophoresis. Pathol Oncol Res. 2022 Jun 28;28:1610308. doi: 10.3389/pore.2022.1610308. PMID: 35837614; PMCID: PMC9274771
2020
Scientists from Elphogene and the Genomac Research Institute in collaboration with leading Czech oncology centers have published an article in the international scientific journal World Journal of Gastroenterology.
The article entitled "Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating DNA tumor" was published on December 28, 2019 and summarizes the results of ctDNA analysis in 47 patients with metastatic colorectal cancer. The main outcome of this article is that ctDNA detection in patients with metastatic colorectal cancer is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment.
Ref.: Pazdirek F, Minarik M, Benesova L, Halkova T, Belsanova B, Macek M, Stepanek L, Hoch J. Monitoring of Early Changes of Circulating Tumor DNA in the Plasma of Rectal Cancer Patients Receiving Neoadjuvant Concomitant Chemoradiotherapy: Evaluation for Prognosis and Prediction of Therapeutic Response. Front Oncol. 2020 Jul 24;10:1028. doi: 10.3389/fonc.2020.01028. PMID: 32793464; PMCID: PMC7394215.
2019
Scientists from Elphogene and the Genomac Research Institute in collaboration with leading Czech oncology centers have published an article in the international scientific journal World Journal of Gastroenterology.
The article entitled "Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating DNA tumor" was published on December 28, 2019 and summarizes the results of ctDNA analysis in 47 patients with metastatic colorectal cancer. The main outcome of this article is that ctDNA detection in patients with metastatic colorectal cancer is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment.
Ref.: Benesova L, Halkova T, Ptackova R, Semyakina A, Menclova K, Pudil J, Ryska M, Levy M, Simsa J, Pazdirek F, Hoch J, Blaha M and Minarik M. Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA. World J Gastroenterol. 2019, 25(48), 6939-6948.
Other publications in international scientific journals
Benesova L, Belsanova B, Minarikova P, Suchanek S, Kopeckova M, Levy M, Lipska L, Visokai V, Zavoral M, Minarik M. Mutation-based detection and monitoring of cell-free tumor DNA in peripheral blood of cancer patients. Anal Biochem. 2013, 433, 227-234.
Levy M, Benesova L, Lipska L, Belsanova B, Minarikova P, Veprekova G, Zavoral M, Minarik M. Utility of Cell-free Tumor DNA for Post-surgical Follow-up of Colorectal Cancer Patients. Anticancer Res. 2012, 32, 1621-1626.
Pesek M., Benesova L., Kopeckova M., Belsanova B., Fiala O., Minarik M. Options for testing DNA mutations and DNA methylation assays of circulating cell-free DNA isolated from peripheral blood of NSCLC patients. Studies Pneumologica et Phthiseologica. 2012, 72, 137-141.